Acetylation of salicylic acid

This is done by reacting the wood with acetic anhydride, which comes from acetic acid known as vinegar when in its dilute form. Crystallization is how the Aspirin product is isolated from the solution, but it requires the chance formation of a few introductory crystals at the beginning.

The product is obtained as colourless crystals, yield 11 g and m. The initial temperature of test tube 2 was It is also believed that the digestion of wood by enzymes initiates at the free hydroxyl sites — which is one of the principal reasons why wood is prone to decay.

The mechanism of the reaction is more complicated than this, however. If necessary, a glass stirring rod may be used to scrap the bottom of the flask to induce crystallization.

Synthesis of aspirin from salicylic acid using acetyl chloride and pyridine

This process is necessary because Aspirin is crystalline at room temperature, but when it is synthesized, it is in solution at a higher temperature. Another laboratory procedure used in this procedure is reading and recording liquid volumes. All four test tubes were clamped into the hot water bath for 5 minutes.

Phosphoric Acid was obtained, and 5 drops were added to test tube 3.


Secondary benefits include the improvement of dimensional stability, improved surface hardness, and no decrease in mechanical properties due to the treatment.

By comparing the actual yield of the reaction and the theoretical yield, one can then find the yield percentage of the experiment. The crude acetylsalicylic acid either solidifies at once, or separates as oil which rapidly crystallises as the stirring proceeds.

With the yield percentage and the purity of the product, one can get an accurate picture of the efficiency of this process. In addition, the acetylation of p53 prevents its binding to the repressor Mdm2 on DNA. After the 5 minutes, the test tubes were checked to insure all solids in the test tubes had dissolved completely.

Synthesis and Characterization of Aspirin

Therefore, STAT3 facilitates oncogenesis in a variety of cell growth related pathways. Under severe DNA damageit also initiates programmed cell death.

The first point of the melting point range is recorded when the first drop formation is observed in the capillary tube, and the second point of the melting point range is recorded once the entire contents of the capillary tube is converted into liquid. Acetylsalicylic Acid is derived from Salicylic acid, which then reacts with Acetyl Anhydride as per the following reaction in Figure 1.Sigma-Aldrich offers a number of Aspirin (Acetyl Salicylic Acid) products.

View information & documentation regarding Aspirin (Acetyl Salicylic Acid. Synthesis of aspirin from salicylic acid 4 Risk Assessment 5 O-acetylation of salicylic acid (Figure 1), which is incorporated into many undergraduate synthetic chemistry laboratory courses.

The purity of the. remaining acetic acid and turn it into acetic acid. The water adds across the anhydride bridge, cleaving it, and releasing two acetic acid molecules. Acetic acid is much less reactive than acetic anhydride. 3. Solubility. Both salicylic Acid and aspirin are slightly soluble in water at room temperature (~ g/mL).

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The present work deals with the synthesis of acetyl salicylic acid by o-acetylation of salicylic acid with acetic anhydride over honeycomb coated with solid acids like ZrO 2 and its modified forms such as Mo(VI)/ZrO 2 & Pt-SO 4 2-/ZrO 2.

Since, these ZrO 2. Principle: Synthesis of aspirin from salicylic acid occurs by acetylation process in acidic medium. Salicylic acid interacts with acetic anhydride in presence of few drops of concentrated sulphuric acid to produce aspirin and a molecule of acetic acid.

Acetylation of salicylic acid
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